Synthesis of aminophosphonate haptens for an aminoacylation reaction between methyl glucoside and a beta-alanyl ester.

Autor: Lintunen T; VTT Technical Research Centre of Finland, Chemical Technology, Espoo., Yli-Kauhaluoma JT
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 Aug 07; Vol. 10 (15), pp. 1749-50.
DOI: 10.1016/s0960-894x(00)00328-0
Abstrakt: Two 2-aminophosphonate haptens derived from methyl alpha-D-glucopyranoside were synthesized to mimic the transition-state of a transesterification reaction between methyl alpha-D-glucopyranoside and 4-nitrophenylester of tert-BOC-beta-alanine. Two sets of monoclonal antibodies were generated against these haptens.
Databáze: MEDLINE