| Autor: |
Hu LY; Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA., Ryder TR, Rafferty MF, Siebers KM, Malone T, Chatterjee A, Feng MR, Lotarski SM, Rock DM, Stoehr SJ, Taylor CP, Weber ML, Miljanich GP, Millerman E, Szoke BG |
| Jazyk: |
angličtina |
| Zdroj: |
Drug design and discovery [Drug Des Discov] 2000; Vol. 17 (1), pp. 85-93. |
| Abstrakt: |
Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and pharmacokinetics of this 4-piperidinylaniline series. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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