Novel surveillance and cure of a donor-transmitted lymphoma in a renal allograft recipient.
| Autor: | Herzig KA; University of Queensland Department of Surgery, Princess Alexandra Hospital, Woolloongabba, Australia., Falk MC, Jonsson JR, Axelsen RA, Griffin AD, Hawley CM, Rigby RJ, Cobcroft R, Nicol DL, Powell EE, Johnson DW |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Transplantation [Transplantation] 2000 Jul 15; Vol. 70 (1), pp. 149-52. |
| Abstrakt: | Background: In this report we describe a malignant lymphoma of donor origin inadvertently transplanted into two renal allograft recipients, despite standard comprehensive donor screening. The successful clearance of the tumor from both patients and a novel method of surveillance are detailed. Methods: Initial management consisted of withdrawal of immunosuppression to promote rejection of the allograft and the transplanted tumor in both patients, followed by graft removal. Peripheral blood microchimerism was assessed in both recipients using nested polymerase chain reaction to detect the DYZ3 gene on the Y chromosome (donor male, recipients female). Results: Although microchimerism was detected on day 6 after transplantation and day 1 after explantation, repeat peripheral blood examination at 1, 3, and 6 months after explantation demonstrated no microchimerism. Both patients remain well at 12 months and have been relisted for transplantation. Conclusion: Despite inadvertent transplantation of a previously undiagnosed malignancy of donor origin, the recipients' immune response was able to eliminate donor tumor cells after the withdrawal of immunosuppression. Repeated surveillance of peripheral blood from both recipients, using a novel application of the technique of nested polymerase chain reaction to amplify donor DNA, demonstrated no persistence of donor cells, supporting effective eradication of the donor malignancy. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|