| Autor: |
Edwards SW; National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Room 8N805, Building 38A, Bethesda, MD 20894, USA. Edwards@ncbi.nlm.nih.gov, Tan CM, Limbird LE |
| Jazyk: |
angličtina |
| Zdroj: |
Trends in pharmacological sciences [Trends Pharmacol Sci] 2000 Aug; Vol. 21 (8), pp. 304-8. |
| DOI: |
10.1016/s0165-6147(00)01513-3 |
| Abstrakt: |
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect