[An experimental study of the role of a blockade of serotonin 5-HT3 receptors and dopamine D2 receptors in the mechanism of the occurrence of early radiation vomiting in monkeys].

Autor: Martirosov KS; State Research Center of Russia, Institute of Biophysics, Moscow. ibkoguc@alara.msk.su, Grigor'ev IuG, Zorin VV, Andrianova IE
Jazyk: ruština
Zdroj: Radiatsionnaia biologiia, radioecologiia [Radiats Biol Radioecol] 2000 May-Jun; Vol. 40 (3), pp. 277-80.
Abstrakt: The experiments with M. fasciculata monkeys exposed to 137Cs gamma-radiation with a dose of 6.9 Gy showed that Latranum, a blocker of serotonin 5-HT3 receptors, is a more efficient antiemetic than Dimetphramidum, a D2 dophamin lytic. This is suggested by fewer animals with emetic reaction of by less severe vomiting in case they have any. The results agree well with a hypothesis that serotonin receptors are dominant in the chemoreceptor trigger zone of monkeys.
Databáze: MEDLINE