| Autor: |
Engel'gardt NV; N. N. Blokhin Russian Cancer Research Center, Moscow., Kudriavtseva EI, Morozova OV, Rudinskaia TD, Turusov VS |
| Jazyk: |
ruština |
| Zdroj: |
Arkhiv patologii [Arkh Patol] 2000 May-Jun; Vol. 62 (3), pp. 24-9. |
| Abstrakt: |
Two transplantable differentiated mouse hepatocarcinomas were obtained in B6 D2 F1 mice from primary tumors induced by initiation (NDEA)-promotion (phenobarbital) protocol. Both HC were slowly growing with time from passage to passage of 5-7 months (s-HC). A fast-growing variant with time between passages of 2-3 weeks appeared in one mouse on the third passage (f-HC). The three HC strains constantly retained their phenotype. The s-HCs were characterized by prominent cell polarity according to organization of the cytoskeleton and distribution of domain-specific membrane-associated markers. Cell polarity was completely destroyed in the fast-growing variant. Cell adhesion in the latter tumor was very low. An in vitro growing strain of f-HC was easily obtained enabling experimental study of regulation of progression in HCs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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