| Autor: |
Criqui GI; Lung Biology Center, Dept of Medicine, University of California, San Francisco 94143-0854, USA., Solomon C, Welch BS, Ferrando RE, Boushey HA, Balmes JR |
| Jazyk: |
angličtina |
| Zdroj: |
The European respiratory journal [Eur Respir J] 2000 May; Vol. 15 (5), pp. 856-62. |
| DOI: |
10.1034/j.1399-3003.2000.15e08.x |
| Abstrakt: |
Exposure of humans to ozone causes increased neutrophils and inflammatory cytokines in airway lining fluid. Recent research shows that macrolide antibiotics may reduce interleukin (IL)-8 production by bronchial epithelial cells and inhibit neutrophil chemotaxis. A double-blind, cross-over study was performed in which 12 healthy subjects underwent two separate 4-h exposures to 0.2 parts per million ozone while exercising intermittently. In the 73.5 h before exposure, subjects were pretreated with either 1,250 mg azithromycin or placebo. Sputum induction conducted 74 h pre- and 18 h post-exposure was used to measure total cells, per cent neutrophils, IL-6, and IL-8. There were significant (p<0.05) pre- to post-exposure increases in total cells, neutrophils, IL-6 and IL-8 in both the azithromycin and placebo arms. However, no significant differences were found between azithromycin and placebo conditions in the post- minus pre-exposure value for these variables. The results suggest that in healthy subjects, in the design used, azithromycin, in usual clinical doses, does not have anti-inflammatory effects on human airways as indicated in the measured variables. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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