| Autor: |
Trenin AS; Research Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow., Tolstykh IV, Terekhova LP, Zenkova VA, Makarova MO, Gladkikh EG, Bychkova OP, Katrujha GS, Dudnik IuV |
| Jazyk: |
ruština |
| Zdroj: |
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 2000; Vol. 45 (4), pp. 6-9. |
| Abstrakt: |
A cyclodepsipeptide antibiotic 86/88 (enniatin B) with strong hypolipidemic action was isolated from the culture liquid of the fungus INA F-86/88 identified as Fusarium lateritium Nees var. stilboides (Wr.) Bilai. In the Hep G2 cell culture the antibiotic suppressed 14C-acetate incorporation into cholesterol (IC50 1.75 microM), cholesterol ethers (IC50 1 microM), triglycerides (IC50 1.3 microM) and free fatty acids (IC50 2.2 microM). The most pronounced effect of the drugs, i.e. the suppression of the cholesterol ethers synthesis is likely due not only to the ACAT inhibition but also to the inhibition of the triglyceride synthesis and the diminishing of the free fatty acids pool in the cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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