| Autor: |
Garbe TR; Mitsubishi Chemical Corporation, Tsukuba Research Center, 8-3-1, Chuo, Ami, Inashiki, Ibaraki, 300-0332 Japan. garbetr@rite.or.jp, Kobayashi M, Shimizu N, Takesue N, Ozawa M, Yukawa H |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2000 May; Vol. 63 (5), pp. 596-8. |
| DOI: |
10.1021/np990517s |
| Abstrakt: |
The novel indole derivatives 2,2-bis(3,3'-indolyl)propionic acid (1); 1,1,1,-tris(3,3',3"-indolyl)ethane (2); and 2,2-bis(3, 3'-indolyl)isocaproic acid (3) were isolated from solvent extracts of indole-supplemented supernatants of Escherichia coli and corynebacteria. The compounds were also obtained by chemical synthesis: compounds 1 and 2 from indole and pyruvic acid and compound 3 from indole and alpha-ketoisocaproic acid, following incubation at 37 degrees C in aqueous medium. Tryptophan and pyruvic acid gave the novel 2-(2-tryptophanyl)lactic acid (4). The condensation reaction between indoles and alpha-keto acids was of general nature, and the mild reaction conditions suggested it may proceed in vivo. Examples for endogenous occurrence may be the neuro-degenerative diseases phenylketonuria and maple syrup urine disease, both characterized by elevated blood levels of alpha-keto acids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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