Determination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of acute and prolonged irradiation.

Autor: Saenko AS; Department of Radiation Biochemistry, Medical Radiological Research Center of RAMS, Obninsk, Russia. mrrc@obninsk.ru, Zamulaeva IA, Smirnova SG, Orlova NV, Selivanova EI, Matveeva NP, Kaplan MA, Nugis VY, Nadezhina NM, Tsyb AF
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2000 May; Vol. 52 (5), pp. 1145-8.
DOI: 10.1016/s0969-8043(00)00061-0
Abstrakt: Somatic mutant frequencies at glycophorin A (GPA) and T-cell receptor (TCR) loci were assessed. The dependence of the GPA mutant frequency on doses of acute and prolonged irradiation was shown. In the case of acute irradiation the GPA mutant frequency displayed a three-fold greater dose-related increase as compared to prolonged irradiation. A dose-dependent increase in the TCR variant frequency was found only in a group of subjects with recent exposures. In Chernobyl clean-up workers the TCR mutant frequency was significantly higher than in control non-irradiated individuals.
Databáze: MEDLINE