| Autor: |
Dad'kov IG; Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk., Kuz'mitskiĭ BB, Antonevich IP, Lakhvich FA |
| Jazyk: |
ruština |
| Zdroj: |
Radiatsionnaia biologiia, radioecologiia [Radiats Biol Radioecol] 2000 Mar-Apr; Vol. 40 (2), pp. 204-7. |
| Abstrakt: |
Methyl ester of 6-oxo-6-[2,2-ethylenedioxy-5-(dimethoxycarbonylmethyl)- cyclopent-1-yl]-hexanoic acid (7-keto-9,9-ethylenedioxiprostanoid, that is analogue of 11-deoxy-PGE1 with modified chains) at concentration 10(-6) mol/l displayed maximal (25%) sensitizing effect when was tested in a range of concentrations 10(-7)-10(-5) mol/l and HeLa cells were gamma-irradiated at dose of 2 Gy, that was compared with metronidazol action. Optimal time of prostanoid contact with cells was between 30 and 60 min, and metronidazol--60 min. Prostanoid effect was exhibited at irradiation doses from 2 to 4 Gy and reached maximum of 46% at 4 Gy, its DMF was 1.5 as well as that of metronidazol. Cytotoxicity of comparable compounds was approximately equal. By its chemical structure and sensitizing features this 7-keto-9,9-ethylenedioxiprostanoid is a prototype of new radiosensitizing drug. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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