| Autor: |
Bruce LA, Behsudi FM, Fawcett CP |
| Jazyk: |
angličtina |
| Zdroj: |
Gastroenterology [Gastroenterology] 1979 May; Vol. 76 (5 Pt 1), pp. 908-12. |
| Abstrakt: |
The mechanism of action of thyrotropin-releasing hormone on antral motility was investigated in vitro. With the recent detection of thyrotropin-releasing hormone in gastrointestinal tissue, the possibility exists that the peptide may play a physiologic role in gastrointestinal motility. Results indicate that the hormone stimulates antral motility through a non-cholinergic excitatory pathway based on the inability of the muscarinic antagonist, atropine, to block the response. A histaminergic pathway is an attractive possibility to explain the excitatory response, because both pyrilamine and cimetidine inhibit the thyrotropin-releasing hormone induced response and the peptide has no further influence on antral motility after the tissue is exposed to a supramaximal concentration of histamine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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