| Autor: |
Kim TS; College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Kwangju, South Korea. taekim@chonnam.ac.kr, Kim SH, Hwang SY |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2000 Jun 15; Vol. 18 (25), pp. 2832-7. |
| DOI: |
10.1016/s0264-410x(00)00075-x |
| Abstrakt: |
To determine whether the paracrine secretion of interleukin-4 (IL-4) can efficiently induce T helper type 2 (Th2) cell-dominated immune response, BLK fibroblasts were stably transfected to secrete IL-4 (750 units/10(6) cells/48 h). Their effects on T helper cell-mediated immune response were investigated in ovalbumin (OVA)-primed C57BL/6 mice, and were compared with those of free recombinant IL-4. Injection with IL-4-secreting fibroblasts (BLK/IL-4) significantly increased anti-OVA IgG1 production in OVA-primed mice. In addition, the BLK/IL-4 cells were more effective than free recombinant IL-4 in decreasing OVA-specific IFN-gamma production and in increasing OVA-specific IL-4 production by splenic CD4(+) T cells. This work suggests that IL-4-secreting fibroblasts can efficiently induce Th2 cell-dominated immune response and may be beneficial in the treatment of diseases caused by undesired Th1 cell-dominated responses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect