| Autor: |
Blann MM; Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA., Morgan DL, Oblender M, Heinen B, Williams J, Tonk VS |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2000 May; Vol. 119 (1), pp. 74-6. |
| DOI: |
10.1016/s0165-4608(99)00209-5 |
| Abstrakt: |
Cytogenetic analysis of bone marrow cells was performed on a 2-year-old African-American male with Down syndrome (DS) and myelodysplastic syndrome (MDS), specifically refractory anemia with excess blasts in transformation (RAEB-T). Chromosome analysis showed, in addition to the constitutional trisomy 21, a trisomy of chromosome 11 and a dup(1)(q23q31). This duplication of 1q is apparently a new chromosomal abnormality in a child with MDS. Partial trisomy of the long arm of chromosome 1 has been reported by several authors and appears to represent a nonrandom chromosomal anomaly in patients with MDS/acute myelogenous leukemia and DS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect