| Autor: |
Maximov GV; School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia. maxim@biophys.msu.ru, Revin VV, Grunyushkin IP, Kols OR |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2000 Apr; Vol. 65 (4), pp. 431-5. |
| Abstrakt: |
Axon excitation increases the number of acetylcholine receptors (ACR) of the Schwann cell (SC) depending on the frequency of rhythmic excitation (RE) and on intercellular concentrations of K+, Ca2+, and acetylcholine. During RE, activity of axonal acetylcholine esterase is decreased, thus providing for high intercellular acetylcholine concentration. Increased intercellular concentration of acetylcholine activates phosphoinositide-specific phospholipase C (PIPLC) of the myelin nerve fiber. During RE, K+ depolarization and acetylcholine exocytosis can activate Ca2+ entry via Ca2+ channels, thus inducing SC ACR phosphorylation mediated by PIPLC stimulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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