| Autor: |
Higuchi K; Department of Radiology and Radiation Oncology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan. nmihashi@sb.gunma-u.ac.jp, Mitsuhashi N, Saitoh J, Maebayashi K, Sakurai H, Akimoto T, Niibe H |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 2000 May 01; Vol. 152 (2), pp. 157-62. |
| DOI: |
10.1016/s0304-3835(99)00449-8 |
| Abstrakt: |
The radiosensitizing effects of caffeine on two rat yolk sac tumor cell lines with a different p53 status were investigated. A reduction of radiation-induced G(2) arrest was caused by caffeine at a concentration of 2 mM in both cell lines. The reduction of survival was observed in a combination of radiation and 2 mM caffeine only in a lower radiation dose range, but not in a higher dose range in NMT-1 with a wild type p53. Radiosensitization of caffeine was recognized even in a higher dose range for cells with a mutant-type p53. Apoptosis, which was not prominent after irradiation alone or caffeine treatment alone, was induced by irradiation in combination with caffeine in cells with a mutant-type p53 through a p53-independent pathway. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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