| Autor: |
Brinkman JA; Department of Chemistry, Seton Hall University, South Orange, New Jersey 07079, USA., Nguyen TT, Sowa JR Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2000 Apr 06; Vol. 2 (7), pp. 981-3. |
| DOI: |
10.1021/ol005653z |
| Abstrakt: |
Rhodium and iridium catalysts containing trifluoromethyl-substituted indenyl ligands (Ind'MCod, Ind' = C9H7, (1-CF3)C9H6, (2-CF3)C9H6, (1,3-CF3)2C9H5) have been developed for the directed hydroboration of 4-(benzyloxy)cyclohexene to cis-3-(benzyloxy)cyclohexanol. Compared to unsubstituted complexes, trifluoromethyl substitution yields a 3-10% increase in selectivity which is attributed to the strong electron-withdrawing effect of the trifluoromethyl group. Rhodium complexes give selectivities of 74-84%, and iridium complexes give high levels of selectivity (93-98%). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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