A sequence similar to bacterial transposable IS elements present in the 5' untranslated region of the bovine butanediol dehydrogenase cDNA.

Autor: Smania AM; Centro de Investigaciones en Química Biológica de Córdoba-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina. asmania@dqbfcq.uncor.edu, Saleh MC, Argaraña CE
Jazyk: angličtina
Zdroj: Genetica [Genetica] 1999; Vol. 105 (3), pp. 233-8.
DOI: 10.1023/a:1003817311179
Abstrakt: A sequence similar to prokaryotic transposable elements was identified in the long 5' untranslated region (5'UTR) of the butanediol dehydrogenase cDNA isolated from a bovine brain lambda gt11 library. Several observations suggested that this sequence could be related to bacterial IS elements: (a) 58% nucleotide sequence identity, (b) 56% amino acid sequence identity, and (c) the presence of inverted terminal repeats. However, nucleotide sequence analyses of the 5'UTR bovine cDNA showed the presence of chain-terminating nucleotide substitutions that would render it incapable of encoding a functional transposase. Finally, it was observed that different vertebrate genomes have sequences related to this putative transposable element.
Databáze: MEDLINE
Externí odkaz: