| Autor: |
Kishima MO; Departamento de Patologia Aplicada, Legislação e Deontologia, Faculdade de Medicina, UEL, Londrina, PR, Brazil., Barbisan LF, Estevão D, Rodrigues MA, Viana de Camargo JL |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 2000 Apr 28; Vol. 152 (1), pp. 37-44. |
| DOI: |
10.1016/s0304-3835(99)00432-2 |
| Abstrakt: |
The interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% energy-restricted diet, both added or not with 50 ppm HCB, for 6 weeks. HCB exposure or energy restriction separately did not exert any influence on the development of glutathione S-transferase placental form (GST-P(+)) foci of hepatocytes. Simultaneous HCB exposure and energy restriction induced a significant increase in liver centrilobular hypertrophy and GST-P(+) foci development. Our findings suggest that energy restriction increases liver response to low dose of HCB, unmasking the promoting potential of this fungicide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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