Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands.

Autor: Allen MP; CNS Discovery, Central Research Division, Pfizer Inc, Groton, CT 06340, USA., Blake JF, Bryce DK, Haggan ME, Liras S, McLean S, Segelstein BE
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 Mar 20; Vol. 10 (6), pp. 523-6.
DOI: 10.1016/s0960-894x(00)00034-2
Abstrakt: 3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1. The compounds exhibit high affinity for the mu opioid receptor.
Databáze: MEDLINE