| Autor: |
Sinclair EJ; Centre for Human Genetics, North Trent Cytogenetics Service, Sheffield, United Kingdom., Jalihal S, Watmore AE |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 2000 Apr 01; Vol. 118 (1), pp. 20-3. |
| DOI: |
10.1016/s0165-4608(99)00173-9 |
| Abstrakt: |
Fluorescence in situ hybridization analysis in an adult with acute monocytic leukemia revealed the complex nature of a rearrangement between chromosomes 10 and 11, which resulted in disruption of the MLL gene. Using a combination of chromosome 10 and 11 paints, a 10 centromere-specific sequence, and a probe for the MLL locus at 11q23, the rearrangement was deduced to have involved a reciprocal translocation between chromosomes 10 and 11, followed by an inversion within the short arm of the derivative 10. To our knowledge, this novel rearrangement has not been described previously. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect