| Autor: |
Goda K; Faculty of Nutrition, Kobe Gakuin University, Japan. goda@nutr.kobegakuin.ac.jp, Hamane Y, Kishimoto R, Ogishi Y |
| Jazyk: |
angličtina |
| Zdroj: |
Advances in experimental medicine and biology [Adv Exp Med Biol] 1999; Vol. 467, pp. 397-402. |
| DOI: |
10.1007/978-1-4615-4709-9_50 |
| Abstrakt: |
Radical scavenging properties of tryptophan metabolites were estimated using their radical reactivity. Metabolites of the kynurenine and the melatonin biosynthesis pathway were mainly examined by use of a kinetical model. Their radical reactivity was determined as the reaction rate constant with a stable free radical, such as galvinoxyl; that is a phenoxy radical. The rate constants of the metabolites have a widely ranged spectrum, which can be divided into three groups. The first group (3-hydroxykynurenine, 3-hydroxyanthranilic acid, and indole-3-pyruvic acid) is more reactive than alpha-tocopherol; the reactivity of the second group (xanthurenic acid, serotonin, N-acetylserotonin) is similar to that of butylated hydroxytoluene (BHT); the third group (kynurenic acid, melatonin, and other ones) is less reactive than BHT. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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