| Autor: |
Petersen R; Department of Anatomy, Institute of Medical Biology, University of Odense, Odense, Denmark., Finsen B, Andreassen OA, Zimmer J, Jørgensen HA |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 2000 Mar 24; Vol. 859 (2), pp. 394-7. |
| DOI: |
10.1016/s0006-8993(00)02017-5 |
| Abstrakt: |
Neuroleptic-induced vacuous chewing movements (VCM) in rats, a putative analogue to tardive dyskinesia in man, may involve degeneration within striatum as well as changes in neurotransmitter and receptor expression. In this study, we measured the expression of dopamine D(1) receptor mRNA by dorsal striatal neurons in rats with high and low level of VCM after treatment with haloperidol for 38 weeks. Both the average integrated density of the in situ hybridization signal and number of cells obtained by the stereological cell counting remained within control level, irrespective of the level of haloperidol-induced oral dyskinesia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect