| Autor: |
van Bree C; Department of Radiotherapy, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands., Savonije JH, Franken NA, Haveman J, Bakker PJ |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of oncology [Int J Oncol] 2000 Apr; Vol. 16 (4), pp. 739-44. |
| DOI: |
10.3892/ijo.16.4.739 |
| Abstrakt: |
The importance of p53-function for the sensitivity to paclitaxel with and without hyperthermia (HT) was studied in an isogenic cell line system. The inactivation of p53 decreased sensitivity to paclitaxel (1.1-2.5-fold), which correlated with a lower induction of apoptosis. The magnitude of the G2/M arrest after treatment with paclitaxel was similar in all cell lines. The cytotoxicity of paclitaxel was not enhanced by HT in either wild-type p53 or p53-inactivated cells. In conclusion, cellular sensitivity to paclitaxel depends on p53-function by its ability to induce apoptosis. Irrespective of the p53-function HT was not able to enhance the sensitivity to paclitaxel. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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