| Autor: |
Sreekumar GP; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA., Smyth JR Jr, Ambady S, Ponce de Leon FA |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of pathology [Am J Pathol] 2000 Mar; Vol. 156 (3), pp. 1099-107. |
| DOI: |
10.1016/S0002-9440(10)64978-4 |
| Abstrakt: |
The Smyth line (SL) chicken, an animal model for autoimmune human vitiligo, is characterized by a spontaneous posthatch pigment loss, determined to be the result of an autoimmune phenomenon. Because endogenous virus (EV) genes have been reported to be associated with a number of autoimmune diseases of human and animal models, we designed this experiment to investigate the role of EV in the SL vitiligo by using the complete sequence of Rous-associated virus-2 as a probe for EV. An F(2) resource population was developed by the matings of SL and parental control (BL) chickens. Linkage disequilibrium between vitiligo and EV was apparent (16.2-kb SacI fragment, P
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| Databáze: |
MEDLINE |
| Externí odkaz: |
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