A randomized controlled trial of a 3-year home exercise program in cystic fibrosis.

Autor: Schneiderman-Walker J; Division of Respiratory Medicine, The Hospital for Sick Children, Departments of Paediatrics and Public Health Sciences, The University of Toronto, Ontario, Canada., Pollock SL, Corey M, Wilkes DD, Canny GJ, Pedder L, Reisman JJ
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2000 Mar; Vol. 136 (3), pp. 304-10.
DOI: 10.1067/mpd.2000.103408
Abstrakt: Objectives: To evaluate the effects of a 3-year home exercise program on pulmonary function and exercise tolerance in mildly to moderately impaired patients with cystic fibrosis (CF) and to assess whether regular aerobic exercise is a realistic treatment option.
Study Design: Seventy-two patients with CF (7-19 years) were randomly assigned to an exercise group (a minimum of 20 minutes of aerobic exercise, at a heart rate of approximately 150 beats/min, 3 times weekly) or a control group (usual physical activity participation). Pulmonary function, exercise tolerance, clinical status, hospitalizations, and compliance with therapy were monitored during scheduled visits to the hospital's CF clinic.
Results: Sixty-five patients were included in the analyses. The control group demonstrated a greater annual decline in percent of predicted forced vital capacity compared with the exercise group (mean slope +/- SD, -2.42 +/- 4.15 vs -0.25 +/- 2.81; P =.02), with a similar trend for forced expiratory volume in 1 second (-3.47 +/- 4.93 vs -1.46 +/- 3. 55; P =.07). Patients remained compliant with the exercise program over the study period. An improved sense of well-being was reported with exercise.
Conclusions: Pulmonary function declined more slowly in the exercise group than in the control group, suggesting a benefit for patients with CF participating in regular aerobic exercise. Consistent compliance with the home exercise program and a self-reported positive attitude toward exercise provide further evidence of the feasibility and value of including an aerobic exercise program in the conventional treatment regimen of patients with CF.
Databáze: MEDLINE
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