Histamine plasma levels and elimination diet in chronic idiopathic urticaria.

Autor: Guida B; Department of Physiology, Nutrition Section, University 'Federico II', Naples, Italy., De Martino CD, De Martino SD, Tritto G, Patella V, Trio R, D'Agostino C, Pecoraro P, D'Agostino L
Jazyk: angličtina
Zdroj: European journal of clinical nutrition [Eur J Clin Nutr] 2000 Feb; Vol. 54 (2), pp. 155-8.
DOI: 10.1038/sj.ejcn.1600911
Abstrakt: Objective: The aim of this study was to evaluate the effects of an oligoantigenic and histamine-free diet on patients affected with chronic idiopathic urticaria (CIU).
Design: Ten patients with chronic idiopathic urticaria were prescribed an oligoantigenic and histamine-free diet for 21 days, followed by serial and controlled reintroduction of foods during a further 70 days. Modification in clinical illness as well as histamine plasma levels, post-heparin plasma diamine oxidase (DAO) and intestinal permeability were evaluated.
Results: The oligoantigenic and histamine-free diet induced a significant improvement of symptoms (P<0.05). Moreover, CIU patients on free diet showed higher histamine plasma levels (P<0. 05 vs post-diet and vs controls) that fell to control levels during the oligoantigenic and histamine-free diet. Post-heparin plasma diamine oxidase values were slightly reduced and were unchanged during the diet as well as intestinal permeability, which was always normal in all patients.
Conclusions: These data suggest that histamine plays a major role in chronic idiopathic urticaria. The finding of normal intestinal permeability suggests that a morphological damage of intestinal mucosa should be excluded in these patients. However, the presence of low levels of post-heparin plasma diamine oxidase may indicate a subclinical impairment of small bowel enterocyte function that could induce a higher sensitivity to histamine-rich or histamine-producing food. European Journal of Clinical Nutrition (2000) 54, 155-158
Databáze: MEDLINE
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