| Autor: |
Jung R; Department of Pharmacy Practice, University of Colorado Health Science Center, Denver, Colorado, USA., Messick CR, Pendland SL, Tesoro EP, Losendahl KJ, Schriever CA, Danziger LH |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2000 Mar; Vol. 44 (3), pp. 778-9. |
| DOI: |
10.1128/AAC.44.3.778-779.2000 |
| Abstrakt: |
The bactericidal activities and postantibiotic effects (PAE) of clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate against Bacteroides fragilis and Peptostreptococcus anaerobius were determined. A concentration of twice the MIC resulted in bactericidal activity against four of four and three of four organisms at 24 h with clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate, respectively. The PAE of clarithromycin-14-hydroxy-clarithromycin was 1.44 to 3.20 h, compared to the less than 1 h of amoxicillin-clavulanate. Clarithromycin-14-hydroxy-clarithromycin possesses good activity against susceptible anaerobes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
