ATM-heterozygous germline mutations contribute to breast cancer-susceptibility.
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| Substance Nomenclature: | 0 (Cell Cycle Proteins) 0 (DNA-Binding Proteins) 0 (Tumor Suppressor Proteins) EC 2.7.11.1 (ATM protein, human) EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins) EC 2.7.11.1 (Protein Serine-Threonine Kinases) |
| Entry Date(s): | Date Created: 20000321 Date Completed: 20000330 Latest Revision: 20211203 |
| Update Code: | 20231215 |
| PubMed Central ID: | PMC1288102 |
| DOI: | 10.1086/302746 |
| PMID: | 10677309 |
| Autor: | Broeks A; Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands., Urbanus JH, Floore AN, Dahler EC, Klijn JG, Rutgers EJ, Devilee P, Russell NS, van Leeuwen FE, van 't Veer LJ |
| Jazyk: | angličtina |
| Zdroj: | American journal of human genetics [Am J Hum Genet] 2000 Feb; Vol. 66 (2), pp. 494-500. |
| DOI: | 10.1086/302746 |
| Abstrakt: | Approximately 0.5%-1% of the general population has been estimated to be heterozygous for a germline mutation in the ATM gene. Mutations in the ATM gene are responsible for the autosomal recessive disorder ataxia-telangiectasia (A-T) (MIM 208900). The finding that ATM-heterozygotes have an increased relative risk for breast cancer was supported by some studies but not confirmed by others. In view of this discrepancy, we examined the frequency of ATM germline mutations in a selected group of Dutch patients with breast cancer. We have analyzed ATM germline mutations in normal blood lymphocytes, using the protein-truncation test followed by genomic-sequence analysis. A high percentage of ATM germline mutations was demonstrated among patients with sporadic breast cancer. The 82 patients included in this study had developed breast cancer at age <45 and had survived >/=5 years (mean 15 years), and in 33 (40%) of the patients a contralateral breast tumor had been diagnosed. Among these patients we identified seven (8.5%) ATM germline mutations, of which five are distinct. One splice-site mutation (IVS10-6T-->G) was detected three times in our series. Four heterozygous carriers were patients with bilateral breast cancer. Our results indicate that the mutations identified in this study are "A-T disease-causing" mutations that might be associated with an increased risk of breast cancer in heterozygotes. We conclude that ATM heterozygotes have an approximately ninefold-increased risk of developing a type of breast cancer characterized by frequent bilateral occurrence, early age at onset, and long-term survival. The specific characteristics of our population of patients may explain why such a high frequency was not found in other series. |
| Databáze: | MEDLINE |
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