The spasmodic peptide defines a new conotoxin superfamily.

-20 region of the peptide precursor. Both the gamma-CRS and the position of the Gla residues in the mature toxin are notably different from other Gla-containing conopeptides. The spasmodic peptide has a novel disulfide framework and distinct signal sequence which together define a new P-superfamily of conopeptides. A cDNA encoding another member of the P-superfamily was identified from a different species, Conus gloriamaris. -->
Grant Information: GM48677 United States GM NIGMS NIH HHS
Substance Nomenclature: 0 (Conotoxins)
0 (Conus textile toxin)
0 (Peptide Fragments)
0 (Peptides)
0 (spasmodic peptide, Conus)
53445-96-8 (1-Carboxyglutamic Acid)
Entry Date(s): Date Created: 20000226 Date Completed: 20000313 Latest Revision: 20190613
Update Code: 20221213
DOI: 10.1021/bi9923712
PMID: 10677206
Autor: Lirazan MB; Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA., Hooper D, Corpuz GP, Ramilo CA, Bandyopadhyay P, Cruz LJ, Olivera BM
Jazyk: angličtina
Zdroj: Biochemistry [Biochemistry] 2000 Feb 22; Vol. 39 (7), pp. 1583-8.
DOI: 10.1021/bi9923712
Abstrakt: We purified and characterized a peptide from the venom of Conus textile that makes normal mice assume the phenotype of a well-known mutant, the spasmodic mouse. This "spasmodic" peptide has 27 amino acids, including two gamma-carboxyglutamate (Gla) residues. A cDNA clone encoding the precursor for the peptide was identified; a gamma-carboxylation recognition signal sequence (gamma-CRS) is present in the -1 --> -20 region of the peptide precursor. Both the gamma-CRS and the position of the Gla residues in the mature toxin are notably different from other Gla-containing conopeptides. The spasmodic peptide has a novel disulfide framework and distinct signal sequence which together define a new P-superfamily of conopeptides. A cDNA encoding another member of the P-superfamily was identified from a different species, Conus gloriamaris.
Databáze: MEDLINE
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