| Autor: |
Nadadur SS; Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. nadadur.srikanth@epamail.epa.gov, Ehrke MJ, Gurtoo HL |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1999 Dec 23; Vol. 1489 (2-3), pp. 433-9. |
| DOI: |
10.1016/s0167-4781(99)00189-x |
| Abstrakt: |
We report the nucleotide sequence of a novel cDNA and TNF-induced expression of the corresponding message (mRNA) in human fibroblast cells. This message is also expressed in certain human tumor cell lines and is over-expressed in a colon cancer cell line (HT-29). NIH3T3 cells transfected with the antisense construct of the 5'-region of this novel cDNA formed 20-fold more colonies in culture compared to cells transfected with a sense construct of the same region or the sense and the antisense constructs of the central region of this cDNA. This observation suggests a possible growth suppressor function for the gene represented by this cDNA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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