| Autor: |
Parada D; Unidad de Investigación, Facultad de Medicina, Universidad Central de Venezuela. parada@cantv.net, Farías RM, García-Tamayo J |
| Jazyk: |
Spanish; Castilian |
| Zdroj: |
Investigacion clinica [Invest Clin] 1999 Dec; Vol. 40 (4), pp. 233-44. |
| Abstrakt: |
Morphometry is a method to detect changes in a variety of tissues through quantitative elements. The purpose of this study was to examine several nuclear morphologic characteristics in normal and neoplastic mammary ductal cells using a multivariable method and expression of estrogen receptors by immunohistochemical techniques. A total of 1879 nuclei were examined by a computerized program, following the detection of estrogen receptors. Nuclear area, perimeter, diameter, maximal and minimal radio were obtained in 439 normal ductal nuclei. The mean nuclear area was 14.45 with a range between 10.88 and 17.90. Variables showed adequate statistical correlation (r > 0.5). A total of 1440 neoplastic nuclei were classified as grades I, II and III, and a statistical significative difference was found between these three groups. We conclude that the nuclear area is a reliable variable for statistical correlation being the ductal nuclei anisotropic objects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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