Effect of calcium supplementation on bone mineral accretion in gambian children accustomed to a low-calcium diet.

Autor:	Dibba B; MRC Keneba, The Gambia, and MRC Human Nutrition Research (formerly MRC Dunn Nutritional Laboratory), Cambridge, United Kingdom., Prentice A, Ceesay M, Stirling DM, Cole TJ, Poskitt EM
Jazyk:	angličtina
Zdroj:	The American journal of clinical nutrition [Am J Clin Nutr] 2000 Feb; Vol. 71 (2), pp. 544-9.
DOI:	10.1093/ajcn/71.2.544
Abstrakt:	Background: Rural Gambian children have poor growth, delayed puberty, a low bone mineral content, and a low calcium intake. Objective: We investigated the effect of a calcium supplement on bone mineral accretion in rural Gambian children. Design: A randomized, double-blind, placebo-controlled study was conducted in 160 children (80 boys, 80 girls) aged 8.3-11.9 y. Bone mineral content (BMC), bone mineral density (BMD), and BMC adjusted for bone width, body weight, and height (size-adjusted BMC) were measured at the midshaft and distal radius. Each child received either 1000 mg Ca/d (as calcium carbonate) or a placebo 5 d/wk for 12 mo. Supplementation increased calcium intake from 342 to 1056 mg/d (8.6 to 26.4 mmol/d). Results: Calcium supplementation resulted in a higher BMC, BMD, and size-adjusted BMC (&xmacr; difference +/- SE): midshaft radius-BMC (3.0 +/- 1.4%; P = 0.034), BMD (4.5 +/- 0.9%; P Conclusions: Increased calcium intake resulted in increased bone mineral status, possibly in association with a decreased bone remodeling space. Further studies are needed to determine whether an increased calcium intake has long-term benefits in Gambian children.
Databáze:	MEDLINE
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