| Autor: |
Laviolette SR; Department of Psychology, University of Toronto, Ontario, Canada., Priebe RP, Yeomans JS |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2000 Jan 01; Vol. 65 (1), pp. 163-74. |
| DOI: |
10.1016/s0091-3057(99)00195-1 |
| Abstrakt: |
Scopolamine (1.5 mg/kg; i.p.) or amphetamine (3 mg/kg; i.p.) increases locomotion and stereotyped behavior patterns in rats. Previous studies suggest that scopolamine acts via muscarinic receptors near the midbrain-pons border. In this study, unilateral microinjections in N-methyl-scopolamine (2.5-10 microg) into the laterodorsal tegmental nucleus (LDT) increased locomotion. Bilateral ibotenate lesions of the LDT attenuated scopolamine-induced locomotion by 68% 7 days postlesion, and by 35% 28 days postlesion. LDT lesions reduced scopolamine-induced stereotypy less than locomotion. The sensitization to amphetamine observed on repeated tests was attenuated by LDT lesions for stereotypy, but not for locomotion. These findings suggest that scopolamine induces locomotion largely, but not exclusively, by blocking muscarinic receptors in LDT. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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