Association between results of ambulatory electrocardiography and development of cardiomyopathy during long-term follow-up of Doberman pinschers.
| Autor: | Calvert CA; Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA., Jacobs GJ, Smith DD, Rathbun SL, Pickus CW |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2000 Jan 01; Vol. 216 (1), pp. 34-9. |
| DOI: | 10.2460/javma.2000.216.34 |
| Abstrakt: | Objective: To characterize ambulatory electrocardiographic results of overtly healthy Doberman Pinschers and determine associations between those results and development of dilated cardiomyopathy. Design: Cohort study. Animals: 114 (58 male, 56 female) overtly healthy Doberman Pinschers without echocardiographic evidence of cardiac disease on initial examination. Procedure: Echocardiograms and 24-hour ambulatory electrocardiograms (Holter recordings) were obtained initially and at variable intervals. The status (live vs dead) of all dogs was known at least 2 years and as long as 10 years after initial examination (mean [+/- SD] follow-up time, 4.33 +/- 1.84 years). Associations between development of dilated cardiomyopathy and number of ventricular premature contractions (VPC), age, and sex were determined. Results: 55 dogs (48%) did not have VPC on initial Holter recordings, and only 8 dogs had > 50 VPC/24 hours. The likelihood that a dog would have VPC was associated with increasing age and being male. At least 1 VPC/24 hours, and in particular, > 50 VPC/24 hours or > or = 1 couplet or triplet of VPC/24 hours, were predictive of subsequent development of dilated cardiomyopathy. Fifty-four dogs (47%) developed dilated cardiomyopathy; 12 were still alive at the end of the study, and 42 had died. Twenty-five of these 42 dogs died after the onset of congestive heart failure (CHF), 15 died suddenly before the onset of overt CHF, and 2 died of noncardiac causes. More males developed dilated cardiomyopathy than females, and dogs that died suddenly were approximately 1 year younger than those that developed CHF. Conclusions and Clinical Relevance: Results of high-quality Holter recordings may be used to identify overtly healthy Doberman Pinschers that are at a high risk for dilated cardiomyopathy. |
| Databáze: | MEDLINE |
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