| Autor: |
Melroe GT; Department of Zoology and Regulatory Biosciences Center, North Dakota State University, Fargo, ND 58105, USA., Ehrman MM, Kittilson JD, Sheridan MA |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 2000 Jan 14; Vol. 465 (2-3), pp. 115-8. |
| DOI: |
10.1016/s0014-5793(99)01723-8 |
| Abstrakt: |
Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose-stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text