Increased blood cobalt and chromium after total hip replacement.
| Autor: | Schaffer AW; Department of Occupational Medicine, University of Vienna, Austria. Andreas.Schaffer@akh-wien.ac.at, Pilger A, Engelhardt C, Zweymueller K, Ruediger HW |
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| Jazyk: | angličtina |
| Zdroj: | Journal of toxicology. Clinical toxicology [J Toxicol Clin Toxicol] 1999; Vol. 37 (7), pp. 839-44. |
| DOI: | 10.1081/clt-100102463 |
| Abstrakt: | Objective: To determine metal concentrations in blood and urine of patients who received cobalt-chromium-alloy metal on metal hip implants. Methods: Cobalt and chromium were determined in blood and urine of 76 patients and 26 controls by electrothermal atomic absorption spectroscopy. Results: A significant postoperative elevation of the metal concentrations was observed for total hip replacement patients in contrast to the control group. Twenty-nine patients exceeded the EKA (Expositionäquivalente für Krebserzeugende Arbeitsstoffe) threshold limits for cobalt in blood and for cobalt and chromium in urine. We obtained a significant correlation between cobalt in blood and cobalt in urine (r = 0.79; p < 0.005), chromium in blood and chromium in urine (r = 0.79; p < 0.005), cobalt in blood and chromium in blood (r = 0.69; p = 0.008), and cobalt in urine and chromium in urine (r = 0.95; p = 0.004). Conclusion: Our findings suggest that in total hip replacements using metal-metal pairings, metal ions of the alloys are released. This release may lead to significantly elevated metal concentrations in biological fluids. Long-term studies are needed to determine the risk of metal-metal implants as a potential cause of cobalt and chromium toxicity. |
| Databáze: | MEDLINE |
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