The thymus in Langerhans' cell histiocytosis.

Autor: Junewick JJ; DeVos Children's Hospital, Grand Rapids, MI 49503, USA., Fitzgerald NE
Jazyk: angličtina
Zdroj: Pediatric radiology [Pediatr Radiol] 1999 Dec; Vol. 29 (12), pp. 904-7.
DOI: 10.1007/s002470050722
Abstrakt: Objective: To determine the frequency of thymic involvement in Langerhans' cell histiocytosis and describe its imaging appearance before and after treatment.
Materials and Methods: A retrospective review of the radiology and clinical records of all patients diagnosed with Langerhans' cell histiocytosis at DeVos Children's Hospital between 1992 and 1998.
Results: Of the 14 patients diagnosed with Langerhans' cell histiocytosis, 7 demonstrated multisystem involvement. The thymus was involved in 5 of 7 patients. The thymus was enlarged in 5; thymic contours were nodular/lobulated in 2; cystic changes were noted in 4; and dystrophic vascular-appearing calcifications were seen in 1. In all cases, findings regressed or resolved following chemotherapy.
Conclusion: The thymus is commonly involved in Langerhans' cell histiocytosis, especially in multisystem disease. Radiologically, the thymus is enlarged and may be smooth or lobulated/nodular in contour, possibly containing cysts and calcifications.
Databáze: MEDLINE
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