| Autor: |
Van Eerdewegh P; Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA., Dupuis J, Santangelo SL, Hayward LB, Blacker D |
| Jazyk: |
angličtina |
| Zdroj: |
Genetic epidemiology [Genet Epidemiol] 1999; Vol. 17 Suppl 1, pp. S373-8. |
| DOI: |
10.1002/gepi.1370170763 |
| Abstrakt: |
Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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