| Autor: |
Prince LS; Department of Pediatrics, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA., Launspach JL, Geller DS, Lifton RP, Pratt JH, Zabner J, Welsh MJ |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of pediatrics [J Pediatr] 1999 Dec; Vol. 135 (6), pp. 786-9. |
| DOI: |
10.1016/s0022-3476(99)70105-8 |
| Abstrakt: |
We report the measurement of transepithelial voltage across the nasal epithelium in a neonate with pseudohypoaldosteronism (PHA) type 1. A 5-day-old infant was seen with hyponatremia, hyperkalemia, and elevated plasma renin and aldosterone levels. Sweat Cl(-) concentration was also increased. Measurements of voltage showed a basal value of zero and the absence of an amiloride-sensitive voltage. However, voltage changed as expected for normal cyclic adenosine monophosphate-stimulated Cl(-) transport. These data demonstrate the absence of amiloride-sensitive Na(+) transport across airway epithelia in a neonate with PHA. The findings suggest that measurements of voltage could be of value in the diagnosis of PHA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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