| Autor: |
Venencie PY; Unité de Dermatologie; INSERM U135 Hormones et Reproduction, Hôpital Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre cedex, France., Méduri G, Pissard S, Jolivet A, Loosfelt H, Milgrom E, Misrahi M |
| Jazyk: |
angličtina |
| Zdroj: |
The British journal of dermatology [Br J Dermatol] 1999 Sep; Vol. 141 (3), pp. 438-46. |
| DOI: |
10.1046/j.1365-2133.1999.03036.x |
| Abstrakt: |
Two different monoclonal antibodies recognizing different epitopes were used to study the localization of luteinizing hormone/human chorionic gonadotrophin (LH/hCG) receptors in human skin. Immunolabelling was observed only in the epidermis and derived structures but not in the dermis. The basal, spinal and granular layers were stained, whereas no receptors were detected in the non-nucleated horny cells. In the growing (anagen) hair, immunostaining was found in the inner root sheath below the level of the sebaceous glands and in the outer root sheath above this level. In the resting (telogen) hair, only the latter staining was observed. In the sebaceous glands, only the thin cells close to the walls of the ducts were immunolabelled. In the eccrine sweat glands, the external clear cells were stained in the secretory portion of the gland, whereas only the cells close to the lumen were labelled in the ducts. The distribution of LH/hCG receptors was compared with that of steroidogenic enzymes (side chain cleavage cytochrome P450, adrenodoxin, 3-beta-hydroxy-5-ene steroid dehydrogenase Delta5-Delta4 isomerase, 17-hydroxylase cytochrome P450 and cytochrome P450 aromatase). Only partial overlaps were observed. The presence of LH receptor mRNA in the skin was confirmed by reverse transcription-polymerase chain reaction. Monoclonal antibodies raised against the human follicle-stimulating hormone receptor failed to detect the latter in the epidermal structures and in the dermis. The role of LH and hCG in skin modifications occurring during pregnancy and after the menopause is unknown. These hormones may possibly act by regulating steroidogenic enzymes or by modulating cell growth and differentiation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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