| Autor: |
Vértesy L; Hoechst Marion Roussel Deutschland GmbH, Frankfurt, Germany., Aretz W, Bonnefoy A, Ehlers E, Kurz M, Markus A, Schiell M, Vogel M, Wink J, Kogler H |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1999 Aug; Vol. 52 (8), pp. 730-41. |
| DOI: |
10.7164/antibiotics.52.730 |
| Abstrakt: |
The actagardine-producing strain Actinoplanes liguriae ATCC 31048, forms an additional lantibiotic when it is cultured on mannitol and soya meal. The new compound, Ala(0)-actagardine (1), has been isolated by solid-phase extraction followed by a two-step chromatographic separation. The molecular formula of 1 is C84H129N21O25S4. Its chemical structure was determined by 2D-NMR analysis and was further confirmed by an amino acid analysis, Edman degradation, and partial synthesis from actagardine. 1 exhibits a slightly higher biological activity than the parent compound actagardine. The synthetic analogs Lys(0)-actagardine (2) and Ile(0)-actagardine (3) demonstrate also antibacterial activities and emphasize the importance of the N-terminus for further derivatization. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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