| Autor: |
Yarim M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey., Sarac S, Ertan M, Batu OS, Erol K |
| Jazyk: |
angličtina |
| Zdroj: |
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1999 Jun 30; Vol. 54 (6), pp. 359-63. |
| DOI: |
10.1016/s0014-827x(99)00042-7 |
| Abstrakt: |
In this study, the synthesis of some new 5-acetyl-3,4-dihydro-6-methyl-4-(substituted phenyl)-2(1H)-pyrimidinones has been reported. The compounds were prepared by the Biginelli reaction of acetylacetone with aromatic aldehydes and urea. The structures of the compounds were characterized by UV, IR, 1H NMR, 13C NRM, mass spectra and elementary analysis. The calcium antagonistic activity of these compounds was tested in vitro on rat ileum precontracted with 4 x 10(-3) M barium chloride. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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