| Autor: |
Li CS; Merck Frosst Centre for Therapeutic Research, Pointe-Clarie-Dorval, Quebec, Canada., Black WC, Brideau C, Chan CC, Charleson S, Cromlish WA, Claveau D, Gauthier JY, Gordon R, Greig G, Grimm E, Guay J, Lau CK, Riendeau D, Thérien M, Visco DM, Wong E, Xu L, Prasit P |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Nov 15; Vol. 9 (22), pp. 3181-6. |
| DOI: |
10.1016/s0960-894x(99)00559-4 |
| Abstrakt: |
By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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