Autor: |
Trekova NA; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow., Vetrilé LA, Basharova LA, Mikovskaia OI, Khlopushina TG |
Jazyk: |
ruština |
Zdroj: |
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova [Zh Vyssh Nerv Deiat Im I P Pavlova] 1999 Sep-Oct; Vol. 49 (5), pp. 799-807. |
Abstrakt: |
Dopamine antibodies (AB) were singularly injected to C57B1/6 mice intraperitoneally. The locomotor activity in the open field was suppressed for 5 days in the majority of the animals. Hyperalgesia revealed 1.5 h and 1 day after the AB injection changed for analgesia on the 5th day. A sharp reduction of the brain level of dopamine and its metabolite was revealed 1 and 5 days after the AB injection, the serotonin content was increased within 1 day and decreased within 5 days after the injection. No action of the AB on cells of the immune system was observed. The possible mechanisms of the AB neurotropic action are discussed. |
Databáze: |
MEDLINE |
Externí odkaz: |
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