Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus in childhood.
| Autor: | Faure-Fontenla MA; Hospital Infantil de México Federico Gómez and Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, DF México., Rodríguez-Suárez RS, Arias-Velásquez R, García-González JE |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of rheumatology [J Rheumatol] 1999 Nov; Vol. 26 (11), pp. 2480-1. |
| Abstrakt: | Objective: Antineutrophil cytoplasmic antibodies (ANCA) have been found in up to 25% of adults with systemic lupus erythematosus (SLE) and in 69% of affected children. We investigated ANCA and antibodies to myeloperoxidase (MPO) in 50 children with SLE. Methods: ANCA in serum were measured by indirect immunofluorescence and antibodies to MPO by ELISA. Results: ANCA were found in 8 (7 perinuclear ANCA, 1 cytoplasmic ANCA) of the 50 sera tested (16%). All the 8 ANCA positive patients were also positive for anti-MPO antibodies. No association with vasculitis or specific organ involvement was observed. Conclusion: Our results in children are roughly similar to those reported for adults. |
| Databáze: | MEDLINE |
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