| Autor: |
Anetseder M; Klinik für Anästhesiologie, Universität Würzburg. ANETS@ANAESTHESIE.UNI-WUERZBURG.DE, Pohl F, Klein R, Müller R, Hoyer A, Horbaschek H, Roggendorf W, Hartung E, Roewer N |
| Jazyk: |
němčina |
| Zdroj: |
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS [Anasthesiol Intensivmed Notfallmed Schmerzther] 1999 Oct; Vol. 34 (10), pp. 626-33. |
| DOI: |
10.1055/s-1999-210 |
| Abstrakt: |
Malignant Hyperthermia (MH) represents a functional myopathy triggered by volatile anesthetics and depolarizing muscle relaxants, and leading to metabolic disturbances of intracellular Calcium homeostasis. Central-Core-like-structures (CCLS) were recently described as central defects in enzyme-histochemical stains and well correlated to the autosomal-dominant MH-predisposition. We studied the correlation of a MH-predisposition with specific myopathological signs. Skeletal muscles of suspected MH-individuals were histochemically stained by SDH-, NADH-, COX-, Gomori-Trichrome-, ATPase-, Acid Phosphatase-, Oil-red O- und PAS-stain und evaluated without knowing MH-diagnosis by the in-vitro-contracture test. Out of 118 patients (30% MHS ["susceptible"], 63% MHN [normal], 7% MHE ["equivocal"]) 19% revealed pathological findings corresponding to CCLS. 45% of these findings were associated with MHS/MHE. With HE-staining internal nuclei were not specific, but increased with the probability of MHS/MHE from 24% to 80%. Central Cores were correlated in 100% with MHS/MHE (4 out of 118 patients). CCLS were found with about similar frequency in skeletal muscle of MHS/MHE and MHN individuals. Internal nuclei were, however, not specifically, associated with MHS. In contrast, Central Cores correlated significantly with MHS/MHE diagnosis. In conclusion, histopathological findings in skeletal muscle seem to be a reliable marker for MH-predisposition only with Central Cores. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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