| Autor: |
Singh PJ; Internal Medicine Service, Jackson Medical Center, MN, USA., Nash JL, Santella RN, Zawada ET Jr |
| Jazyk: |
angličtina |
| Zdroj: |
South Dakota journal of medicine [S D J Med] 1999 Oct; Vol. 52 (10), pp. 377-80. |
| Abstrakt: |
A case of refractory hypomagnesemia associated with hypokalemic alkalosis and hypocalciuria (Gitelman's syndrome) is described. The genetic mutations discovered to cause the hypokalemic alkalotic syndromes are described (the thiazide-sensitive sodium chloride co-transporter gene or TSC mutations in Gitelman's syndrome, and the sodium-potassium-chloride co-transporter gene or NKCC2 mutations in Bartter's syndrome). The molecular, electrolyte, and volume abnormalities are described, and the implications for diagnosis, therapy, and future research discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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