| Autor: |
Subrahmanyam D; Natural Products Division, Dr Reddy's Research Foundation, Miyapur, Hyderabad, AP, India., Sarma VM, Venkateswarlu A, Sastry TV, Kulakarni AP, Rao DS, Reddy KV |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry [Bioorg Med Chem] 1999 Sep; Vol. 7 (9), pp. 2013-20. |
| DOI: |
10.1016/s0968-0896(99)00130-3 |
| Abstrakt: |
A number of 5-aminosubstituted 20(S)-camptothecin analogues were prepared via semi-synthesis starting from 20(S)-camptothecin and 9-methoxy 20(S)-camptothecin. In vitro anti-cancer activity of these analogues was determined using 60 human tumor cell line assay. Although water solubility of most of these compounds was improved compared to 20(S)-camptothecin, their anti-cancer activity was considerably diminished. However, only smaller substituents such as methylamine or hydroxylamine as present in 8s and 8t, respectively, showed good activity with improved water solubility. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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