| Autor: |
Craig AS; Tennessee Department of Health, Communicable and Environmental Disease Services, Nashville, TN 37247-5281, USA. acraig@mail.state.tn.us, Erwin PC, Schaffner W, Elliott JA, Moore WL, Ussery XT, Patterson L, Dake AD, Hannah SG, Butler JC |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 1999 Nov; Vol. 29 (5), pp. 1257-64. |
| DOI: |
10.1086/313451 |
| Abstrakt: |
Three cases of meningitis due to multidrug-resistant serotype 14 Streptococcus pneumoniae occurred at a day care center (DCC) over 5 days. Cultures of nasopharyngeal samples were done at the index DCC, 2 comparison DCCs, and a pediatrics practice. Isolates were serotyped and subtyped by pulsed-field gel electrophoresis (PFGE) with SmaI. Pneumococcal carriage rates ranged from 44%-65% at the 3 DCCs and 29% in the pediatrics practice. Carriage of multidrug-resistant serotype 14 S. pneumoniae was noted in 13%-19% of children at the 3 DCCs. An outbreak strain was identified by PFGE at the index DCC and 1 other DCC; a closely related strain was found in the third DCC. Carriage of the outbreak strain was associated with being age 0-24 months, antibiotic use, upper respiratory tract infections, and otitis media. DCC contacts of the ill children were offered chemoprophylaxis with rifampin and clindamycin, which produced a profound but transient decrease in carriage. No additional cases occurred. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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